Cargando…

Mechanism of Cross-Resistance to Fusion Inhibitors Conferred by the K394R Mutation in Respiratory Syncytial Virus Fusion Protein

The fusion glycoprotein (F) is essential for respiratory syncytial virus (RSV) entry and has become an attractive target for anti-RSV drug development. Despite the promising prospect of RSV F inhibitors, issues of drug resistance remain challenging. In this study, we established a dual-luciferase pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Wei, Li, Yueyue, Song, Qiaoyun, Wang, Ziqin, Li, Manmei, Zhang, Qiwei, Wang, Ying, Ye, Wencai, Li, Yaolan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Virus-Cell Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475503/ https://www.ncbi.nlm.nih.gov/pubmed/34379500 http://dx.doi.org/10.1128/JVI.01205-21

Ejemplares similares

Respiratory Syncytial Virus Infection Does Not Induce Epithelial-Mesenchymal Transition
por: Talukdar, Sattya N., et al.
Publicado: (2023)

Cyclophilin A Inhibits Human Respiratory Syncytial Virus (RSV) Replication by Binding to RSV-N through Its PPIase Activity
por: Liang, Wenzhang, et al.
Publicado: (2021)

Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Gαi Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies
por: Li, Jiao, et al.
Publicado: (2022)

In Vitro Enhancement of Respiratory Syncytial Virus Infection by Maternal Antibodies Does Not Explain Disease Severity in Infants
por: van Erp, Elisabeth A., et al.
Publicado: (2017)

An Unexpected Encounter: Respiratory Syncytial Virus Nonstructural Protein 1 Interacts with Mediator Subunit MED25
por: Van Royen, Tessa, et al.
Publicado: (2022)

Interferon-Induced Transmembrane Protein 3 Is a Virus-Associated Protein Which Suppresses Porcine Reproductive and Respiratory Syndrome Virus Replication by Blocking Viral Membrane Fusion
por: Zhang, Angke, et al.
Publicado: (2020)

Long Noncoding RNA NRAV Promotes Respiratory Syncytial Virus Replication by Targeting the MicroRNA miR-509-3p/Rab5c Axis To Regulate Vesicle Transportation
por: Li, Jian, et al.
Publicado: (2020)

Biochemical Analysis of Coronavirus Spike Glycoprotein Conformational Intermediates during Membrane Fusion
por: Kawase, Miyuki, et al.
Publicado: (2019)

Respiratory Syncytial Virus Sequesters NF-κB Subunit p65 to Cytoplasmic Inclusion Bodies To Inhibit Innate Immune Signaling
por: Jobe, Fatoumatta, et al.
Publicado: (2020)

Multiple Respiratory Syncytial Virus (RSV) Strains Infecting HEp-2 and A549 Cells Reveal Cell Line-Dependent Differences in Resistance to RSV Infection
por: Rajan, Anubama, et al.
Publicado: (2022)

Respiratory Syncytial Virus Activates Rab5a To Suppress IRF1-Dependent Lambda Interferon Production, Subverting the Antiviral Defense of Airway Epithelial Cells
por: Mo, Shi, et al.
Publicado: (2021)

Single-Virus Fusion Measurements Reveal Multiple Mechanistically Equivalent Pathways for SARS-CoV-2 Entry
por: Sengar, Anjali, et al.
Publicado: (2023)

Highly Efficient SARS-CoV-2 Infection of Human Cardiomyocytes: Spike Protein-Mediated Cell Fusion and Its Inhibition
por: Navaratnarajah, Chanakha K., et al.
Publicado: (2021)

SARS-CoV-2 and SARS-CoV Spike-Mediated Cell-Cell Fusion Differ in Their Requirements for Receptor Expression and Proteolytic Activation
por: Hörnich, Bojan F., et al.
Publicado: (2021)

N-(4-Hydroxyphenyl) Retinamide Suppresses SARS-CoV-2 Spike Protein-Mediated Cell-Cell Fusion by a Dihydroceramide Δ4-Desaturase 1-Independent Mechanism
por: Hayashi, Yasuhiro, et al.
Publicado: (2021)

CP204L Is a Multifunctional Protein of African Swine Fever Virus That Interacts with the VPS39 Subunit of the Homotypic Fusion and Vacuole Protein Sorting Complex and Promotes Lysosome Clustering
por: Dolata, Katarzyna Magdalena, et al.
Publicado: (2023)

Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization
por: Kleine-Weber, Hannah, et al.
Publicado: (2019)

Replication of Severe Acute Respiratory Syndrome Coronavirus 2 in Human Respiratory Epithelium
por: Milewska, Aleksandra, et al.
Publicado: (2020)

Tumor Susceptibility Gene 101 (TSG101) Contributes to Virion Formation of Porcine Reproductive and Respiratory Syndrome Virus via Interaction with the Nucleocapsid (N) Protein along with the Early Secretory Pathway
por: Zhang, Longxiang, et al.
Publicado: (2022)

Porcine Reproductive and Respiratory Syndrome Virus Utilizes Viral Apoptotic Mimicry as an Alternative Pathway To Infect Host Cells
por: Wei, Xin, et al.
Publicado: (2020)

V367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity
por: Ou, Junxian, et al.
Publicado: (2021)

Reovirus genomic diversity confers plasticity for protease utility during adaptation to intracellular uncoating
por: Lin, Qi Feng, et al.
Publicado: (2023)

Porcine Reproductive and Respiratory Syndrome Virus nsp11 Antagonizes Type I Interferon Signaling by Targeting IRF9
por: Wang, Dang, et al.
Publicado: (2019)

A Naturally Occurring Domestic Cat APOBEC3 Variant Confers Resistance to Feline Immunodeficiency Virus Infection
por: Yoshikawa, Rokusuke, et al.
Publicado: (2015)

The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K Is Species Specific
por: Lodermeyer, Veronika, et al.
Publicado: (2018)

Lactoferrin-Hexon Interactions Mediate CAR-Independent Adenovirus Infection of Human Respiratory Cells
por: Persson, B. David, et al.
Publicado: (2020)

CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner
por: Furlong, Kevin, et al.
Publicado: (2020)

PSMD12-Mediated M1 Ubiquitination of Influenza A Virus at K102 Regulates Viral Replication
por: Hui, Xianfeng, et al.
Publicado: (2022)

Tracking the Replication-Competent Zika Virus with Tetracysteine-Tagged Capsid Protein in Living Cells
por: Li, Shimin, et al.
Publicado: (2022)

Respiratory Tract Explant Infection Dynamics of Influenza A Virus in California Sea Lions, Northern Elephant Seals, and Rhesus Macaques
por: Liu, Hongwei, et al.
Publicado: (2021)

Foot-and-Mouth Disease Virus VP3 Protein Acts as a Critical Proinflammatory Factor by Promoting Toll-Like Receptor 4-Mediated Signaling
por: Zhang, Jing, et al.
Publicado: (2021)

Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection
por: Burkard, Christine, et al.
Publicado: (2018)

A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication
por: Weston, Stuart, et al.
Publicado: (2019)

The “LLQY” Motif on SARS-CoV-2 Spike Protein Affects S Incorporation into Virus Particles
por: Du, Shouwen, et al.
Publicado: (2022)

Porcine Epidemic Diarrhea Virus Infection Disrupts the Nasal Endothelial Barrier To Favor Viral Dissemination
por: Li, Jianda, et al.
Publicado: (2022)

Genome-Wide Gene Expression Analysis Identifies the Proto-oncogene Tyrosine-Protein Kinase Src as a Crucial Virulence Determinant of Infectious Laryngotracheitis Virus in Chicken Cells
por: Li, Hai, et al.
Publicado: (2015)

Host Cellular Protein TRAPPC6AΔ Interacts with Influenza A Virus M2 Protein and Regulates Viral Propagation by Modulating M2 Trafficking
por: Zhu, Pengyang, et al.
Publicado: (2016)

The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy-Mediated Lysosomal Degradation of TBK1
por: Sun, Maowen, et al.
Publicado: (2022)

Interferon-Inducible Oligoadenylate Synthetase-Like Protein Acts as an Antiviral Effector against Classical Swine Fever Virus via the MDA5-Mediated Type I Interferon-Signaling Pathway
por: Li, Lian-Feng, et al.
Publicado: (2017)

Mitogen-Activated Protein Kinase Kinase 2, a Novel E2-Interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway
por: Wang, Jinghan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_fh3funmc1duhtv8ghv2ll7nukg