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Focal Dorsal Hippocampal Nav1.1 Knock Down Alters Place Cell Temporal Coordination and Spatial Behavior

Alterations in the voltage-gated sodium channel Nav.1.1 are implicated in various neurological disorders, including epilepsy, Alzheimer’s disease, and autism spectrum disorders. Previous studies suggest that the reduction of Nav1.1 expression leads to a decrease of fast spiking activity in inhibitor...

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Detalles Bibliográficos
Autores principales: Sakkaki, Sophie, Barrière, Sylvain, Bender, Alex C, Scott, Rod C, Lenck-Santini, Pierre-Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475810/
https://www.ncbi.nlm.nih.gov/pubmed/32377688
http://dx.doi.org/10.1093/cercor/bhaa101