Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition

HECT ubiquitin ligases play essential roles in metazoan development and physiology. The HECT ligase HUWE1 is central to the cellular stress response by mediating degradation of key death or survival factors, including Mcl1, p53, DDIT4, and Myc. Although mutations in HUWE1 and related HECT ligases ar...

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Detalles Bibliográficos
Autores principales: Hunkeler, Moritz, Jin, Cyrus Y., Ma, Michelle W., Monda, Julie K., Overwijn, Daan, Bennett, Eric J., Fischer, Eric S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476073/
https://www.ncbi.nlm.nih.gov/pubmed/34314700
http://dx.doi.org/10.1016/j.molcel.2021.06.032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476073/
https://www.ncbi.nlm.nih.gov/pubmed/34314700
http://dx.doi.org/10.1016/j.molcel.2021.06.032

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