Cargando…

Single-molecule imaging reveals the concerted release of myosin from regulated thin filaments

Regulated thin filaments (RTFs) tightly control striated muscle contraction through calcium binding to troponin, which enables tropomyosin to expose myosin-binding sites on actin. Myosin binding holds tropomyosin in an open position, exposing more myosin-binding sites on actin, leading to cooperativ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smith, Quentin M, Inchingolo, Alessio V, Mihailescu, Madalina-Daniela, Dai, Hongsheng, Kad, Neil M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476120/ https://www.ncbi.nlm.nih.gov/pubmed/34569933 http://dx.doi.org/10.7554/eLife.69184

Ejemplares similares

Revealing the mechanism of how cardiac myosin-binding protein C N-terminal fragments sensitize thin filaments for myosin binding
por: Inchingolo, Alessio V., et al.
Publicado: (2019)

Using Fluorescent Myosin to Directly Visualize Cooperative Activation of Thin Filaments
por: Desai, Rama, et al.
Publicado: (2015)

Single molecule mechanics resolves the earliest events in force generation by cardiac myosin
por: Woody, Michael S, et al.
Publicado: (2019)

Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor
por: Louet, Maxime, et al.
Publicado: (2021)

To lie or not to lie: Super-relaxing with myosins
por: Nag, Suman, et al.
Publicado: (2021)

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function
por: Morck, Makenna M, et al.
Publicado: (2022)

Rad52-Rad51 association is essential to protect Rad51 filaments against Srs2, but facultative for filament formation
por: Ma, Emilie, et al.
Publicado: (2018)

Conformational distributions of isolated myosin motor domains encode their mechanochemical properties
por: Porter, Justin R, et al.
Publicado: (2020)

Profilin and formin constitute a pacemaker system for robust actin filament growth
por: Funk, Johanna, et al.
Publicado: (2019)

Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation
por: Hansen, Jesse M, et al.
Publicado: (2021)

Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil
por: Snoberger, Aaron, et al.
Publicado: (2021)

Structure of Geobacter OmcZ filaments suggests extracellular cytochrome polymers evolved independently multiple times
por: Wang, Fengbin, et al.
Publicado: (2022)

Direct Measurements of Local Coupling between Myosin Molecules Are Consistent with a Model of Muscle Activation
por: Walcott, Sam, et al.
Publicado: (2015)

Myosin essential light chain 1sa decelerates actin and thin filament gliding on β-myosin molecules
por: Osten, Jennifer, et al.
Publicado: (2022)

Modulating FOXO3 transcriptional activity by small, DBD-binding molecules
por: Hagenbuchner, Judith, et al.
Publicado: (2019)

Concerted regulation of ISWI by an autoinhibitory domain and the H4 N-terminal tail
por: Ludwigsen, Johanna, et al.
Publicado: (2017)

Visualizing molecules of functional human profilin
por: Pimm, Morgan L, et al.
Publicado: (2022)

USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
por: Ruiz, E Josue, et al.
Publicado: (2021)

Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens
por: Amberg-Johnson, Katherine, et al.
Publicado: (2017)

Bayesian machine learning analysis of single-molecule fluorescence colocalization images
por: Ordabayev, Yerdos A, et al.
Publicado: (2022)

Single-molecule analysis of the entire perfringolysin O pore formation pathway
por: McGuinness, Conall, et al.
Publicado: (2022)

Dynamics of ribosomes and release factors during translation termination in E. coli
por: Adio, Sarah, et al.
Publicado: (2018)

Structure and ion-release mechanism of P(IB-4)-type ATPases
por: Grønberg, Christina, et al.
Publicado: (2021)

In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin
por: Tilly, Ben C, et al.
Publicado: (2021)

A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution
por: Paudel, Bishnu P, et al.
Publicado: (2020)

Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells
por: Plesch, Eva, et al.
Publicado: (2018)

Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis
por: Zhao, Gengjing, et al.
Publicado: (2017)

Single-molecule functional anatomy of endogenous HER2-HER3 heterodimers
por: Choi, Byoungsan, et al.
Publicado: (2020)

Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation
por: Smith, Benjamin A, et al.
Publicado: (2013)

Elongation inhibitors do not prevent the release of puromycylated nascent polypeptide chains from ribosomes
por: Hobson, Benjamin D, et al.
Publicado: (2020)

Organic electrochemical transistor arrays for real-time mapping of evoked neurotransmitter release in vivo
por: Xie, Kai, et al.
Publicado: (2020)

Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation
por: Hou, Xiaowei, et al.
Publicado: (2020)

Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release
por: Bibel, Brianna, et al.
Publicado: (2022)

Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion
por: Duroc, Yann, et al.
Publicado: (2017)

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia
por: Hu, Xuchen, et al.
Publicado: (2019)

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite
por: Ramaprasad, Abhinay, et al.
Publicado: (2022)

Large-scale filament formation inhibits the activity of CTP synthetase
por: Barry, Rachael M, et al.
Publicado: (2014)

Bacterial actin MreB forms antiparallel double filaments
por: van den Ent, Fusinita, et al.
Publicado: (2014)

The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes
por: Wong, Yao Liang, et al.
Publicado: (2018)

JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes
por: Lee, Schuyler, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pgtqnfu3rv7880uo21s88ndpss