Structural insights into the activation of human calcium-sensing receptor

Human calcium-sensing receptor (CaSR) is a G-protein-coupled receptor that maintains Ca(2+) homeostasis in serum. Here, we present the cryo-electron microscopy structures of the CaSR in the inactive and agonist+PAM bound states. Complemented with previously reported structures of CaSR, we show that...

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Detalles Bibliográficos
Autores principales: Chen, Xiaochen, Wang, Lu, Cui, Qianqian, Ding, Zhanyu, Han, Li, Kou, Yongjun, Zhang, Wenqing, Wang, Haonan, Jia, Xiaomin, Dai, Mei, Shi, Zhenzhong, Li, Yuying, Li, Xiyang, Geng, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476121/
https://www.ncbi.nlm.nih.gov/pubmed/34467854
http://dx.doi.org/10.7554/eLife.68578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476121/
https://www.ncbi.nlm.nih.gov/pubmed/34467854
http://dx.doi.org/10.7554/eLife.68578

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