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Structural insights into the activation of human calcium-sensing receptor

Human calcium-sensing receptor (CaSR) is a G-protein-coupled receptor that maintains Ca(2+) homeostasis in serum. Here, we present the cryo-electron microscopy structures of the CaSR in the inactive and agonist+PAM bound states. Complemented with previously reported structures of CaSR, we show that...

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Detalles Bibliográficos
Autores principales:	Chen, Xiaochen, Wang, Lu, Cui, Qianqian, Ding, Zhanyu, Han, Li, Kou, Yongjun, Zhang, Wenqing, Wang, Haonan, Jia, Xiaomin, Dai, Mei, Shi, Zhenzhong, Li, Yuying, Li, Xiyang, Geng, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476121/ https://www.ncbi.nlm.nih.gov/pubmed/34467854 http://dx.doi.org/10.7554/eLife.68578

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