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The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish

Amyloid precursor protein (APP) is expressed in many tissues in human, mice and in zebrafish. In zebrafish, there are two orthologues, Appa and Appb. Interestingly, some cellular processes associated with APP overlap with cilia-mediated functions. Whereas the localization of APP to primary cilia of...

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Detalles Bibliográficos
Autores principales: Chebli, Jasmine, Rahmati, Maryam, Lashley, Tammaryn, Edeman, Brigitta, Oldfors, Anders, Zetterberg, Henrik, Abramsson, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476544/
https://www.ncbi.nlm.nih.gov/pubmed/34580355
http://dx.doi.org/10.1038/s41598-021-98487-7