Cargando…

Mapping the glycosyltransferase fold landscape using interpretable deep learning

Glycosyltransferases (GTs) play fundamental roles in nearly all cellular processes through the biosynthesis of complex carbohydrates and glycosylation of diverse protein and small molecule substrates. The extensive structural and functional diversification of GTs presents a major challenge in mappin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Taujale, Rahil, Zhou, Zhongliang, Yeung, Wayland, Moremen, Kelley W., Li, Sheng, Kannan, Natarajan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476585/ https://www.ncbi.nlm.nih.gov/pubmed/34580305 http://dx.doi.org/10.1038/s41467-021-25975-9

Ejemplares similares

Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases
por: Taujale, Rahil, et al.
Publicado: (2020)

Modularity of the hydrophobic core and evolution of functional diversity in fold A glycosyltransferases
por: Venkat, Aarya, et al.
Publicado: (2022)

Evolution of Functional Diversity in the Holozoan Tyrosine Kinome
por: Yeung, Wayland, et al.
Publicado: (2021)

KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases
por: Huang, Liang-Chin, et al.
Publicado: (2021)

Tree visualizations of protein sequence embedding space enable improved functional clustering of diverse protein superfamilies
por: Yeung, Wayland, et al.
Publicado: (2023)

Glycosyltransferase Family 43 Is Also Found in Early Eukaryotes and Has Three Subfamilies in Charophycean Green Algae
por: Taujale, Rahil, et al.
Publicado: (2015)

Alignment-free estimation of sequence conservation for identifying functional sites using protein sequence embeddings
por: Yeung, Wayland, et al.
Publicado: (2023)

Comparison of human poly-N-acetyl-lactosamine synthase structure with GT-A fold glycosyltransferases supports a modular assembly of catalytic subsites
por: Kadirvelraj, Renuka, et al.
Publicado: (2020)

Phosformer: an explainable transformer model for protein kinase-specific phosphorylation predictions
por: Zhou, Zhongliang, et al.
Publicado: (2023)

Functional classification and validation of yeast prenylation motifs using machine learning and genetic reporters
por: Berger, Brittany M., et al.
Publicado: (2022)

Characterizing chromatin folding coordinate and landscape with deep learning
por: Xie, Wen Jun, et al.
Publicado: (2020)

Peters plus syndrome mutations affect the function and stability of human β1,3-glucosyltransferase
por: Zhang, Ao, et al.
Publicado: (2021)

A Toxoplasma Prolyl Hydroxylase Mediates Oxygen Stress Responses by Regulating Translation Elongation
por: Florimond, Celia, et al.
Publicado: (2019)

The highly conserved domain of unknown function 1792 has a distinct glycosyltransferase fold
por: Zhang, Hua, et al.
Publicado: (2014)

A Glycan Array‐Based Assay for the Identification and Characterization of Plant Glycosyltransferases
por: Ruprecht, Colin, et al.
Publicado: (2020)

Mapping the topography of spatial gene expression with interpretable deep learning
por: Chitra, Uthsav, et al.
Publicado: (2023)

Unveiling the activation dynamics of a fold-switch bacterial glycosyltransferase by (19)F NMR
por: Liebau, Jobst, et al.
Publicado: (2020)

Conservation of Atypical Allostery in C. elegans UDP-Glucose Dehydrogenase
por: Beattie, Nathaniel R., et al.
Publicado: (2019)

The Somatic Mutation Landscape of UDP-Glycosyltransferase (UGT) Genes in Human Cancers
por: Hu, Dong Gui, et al.
Publicado: (2022)

PlantCAZyme: a database for plant carbohydrate-active enzymes
por: Ekstrom, Alexander, et al.
Publicado: (2014)

Mapping the Kinetic Barriers of a Large RNA Molecule's Folding Landscape
por: Schlatterer, Jörg C., et al.
Publicado: (2014)

The Landscape of Using Glycosyltransferase Gene Signatures for Overall Survival Prediction in Hepatocellular Carcinoma
por: Cai, Qiang, et al.
Publicado: (2022)

Deep learning interpretation of echocardiograms
por: Ghorbani, Amirata, et al.
Publicado: (2020)

DeepSF: deep convolutional neural network for mapping protein sequences to folds
por: Hou, Jie, et al.
Publicado: (2018)

Quantitative Structure–Mutation–Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction
por: Huang, Liang-Chin, et al.
Publicado: (2020)

Pseudoknots in RNA folding landscapes
por: Kucharík, Marcel, et al.
Publicado: (2016)

Folding non-homologous proteins by coupling deep-learning contact maps with I-TASSER assembly simulations
por: Zheng, Wei, et al.
Publicado: (2021)

Assessment of the uncertainty and interpretability of deep learning models for mapping soil salinity using DeepQuantreg and game theory
por: Mohammadifar, Aliakbar, et al.
Publicado: (2022)

Interpretation of deep learning in genomics and epigenomics
por: Talukder, Amlan, et al.
Publicado: (2020)

GTDB: an integrated resource for glycosyltransferase sequences and annotations
por: Zhou, Chenfen, et al.
Publicado: (2020)

Effector Glycosyltransferases in Legionella
por: Belyi, Yury, et al.
Publicado: (2011)

Higher plant glycosyltransferases
por: Ross, Joe, et al.
Publicado: (2001)

Processivity in Bacterial Glycosyltransferases
por: Yakovlieva, Liubov, et al.
Publicado: (2019)

Application of an interpretable classification model on Early Folding Residues during protein folding
por: Bittrich, Sebastian, et al.
Publicado: (2019)

Improving Protein Fold Recognition by Deep Learning Networks
por: Jo, Taeho, et al.
Publicado: (2015)

Evolution of the folding landscape of effector caspases
por: Shrestha, Suman, et al.
Publicado: (2021)

Interpreting the role of nuchal fold for fetal growth restriction prediction using machine learning
por: Teng, Lung Yun, et al.
Publicado: (2022)

CRISPRL and: Interpretable large-scale inference of DNA repair landscape based on a spectral approach
por: Aghazadeh, Amirali, et al.
Publicado: (2020)

Automatic interpretation of otoliths using deep learning
por: Moen, Endre, et al.
Publicado: (2018)

Glycosylation of Ganoderic Acid G by Bacillus Glycosyltransferases
por: Wu, Jiumn-Yih, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_l31kerl1ucp4ca4sh99knd2akh