Cargando…

Integrated genomics point to immune vulnerabilities in pleural mesothelioma

Pleural mesothelioma is an aggressive malignancy with limited effective therapies. In order to identify therapeutic targets, we integrated SNP genotyping, sequencing and transcriptomics from tumours and low-passage patient-derived cells. Previously unrecognised deletions of SUFU locus (10q24.32), ob...

Descripción completa

Detalles Bibliográficos
Autores principales: Nastase, Anca, Mandal, Amit, Lu, Shir Kiong, Anbunathan, Hima, Morris-Rosendahl, Deborah, Zhang, Yu Zhi, Sun, Xiao-Ming, Gennatas, Spyridon, Rintoul, Robert C., Edwards, Matthew, Bowman, Alex, Chernova, Tatyana, Benepal, Tim, Lim, Eric, Taylor, Anthony Newman, Nicholson, Andrew G., Popat, Sanjay, Willis, Anne E., MacFarlane, Marion, Lathrop, Mark, Bowcock, Anne M., Moffatt, Miriam F., Cookson, William O. C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476593/
https://www.ncbi.nlm.nih.gov/pubmed/34580349
http://dx.doi.org/10.1038/s41598-021-98414-w