Effect of CYP3A4 metabolism on sex differences in the pharmacokinetics and pharmacodynamics of zolpidem

To investigate pharmacokinetic and pharmacodynamic differences of zolpidem between males and females and their causes, including CYP3A4 activity. A single oral dose of zolpidem (10 mg) was administered to 15 male and 15 female healthy subjects. Blood samples were collected up to 12 h post-dose to de...

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Detalles Bibliográficos
Autores principales: Yoon, Seonghae, Jeong, Seongmee, Jung, Eben, Kim, Ki Soon, Jeon, Inseung, Lee, Yujin, Cho, Joo-Youn, Oh, Woo-Yong, Chung, Jae-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476623/
https://www.ncbi.nlm.nih.gov/pubmed/34580385
http://dx.doi.org/10.1038/s41598-021-98689-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476623/
https://www.ncbi.nlm.nih.gov/pubmed/34580385
http://dx.doi.org/10.1038/s41598-021-98689-z

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