The Optimal Lipid Chain Length of a Membrane-Permeabilizing Lipopeptide Results From the Balance of Membrane Partitioning and Local Damage

Pseudodesmin A (PSD) is a cyclic lipodepsipeptide produced by Pseudomonas that kills certain bacteria at MIC(1/2) in the single micromolar range, probably by permeabilizing their cellular membranes. Synthetic PSD variants, where the native decanoic (C10) acyl chain is varied in length from C4 to C8...

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Detalles Bibliográficos
Autores principales: Steigenberger, Jessica, Verleysen, Yentl, Geudens, Niels, Martins, José C., Heerklotz, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476953/
https://www.ncbi.nlm.nih.gov/pubmed/34594308
http://dx.doi.org/10.3389/fmicb.2021.669709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476953/
https://www.ncbi.nlm.nih.gov/pubmed/34594308
http://dx.doi.org/10.3389/fmicb.2021.669709

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