Innovation in the discovery of the HIV-1 attachment inhibitor temsavir and its phosphonooxymethyl prodrug fostemsavir

The discovery and development of fostemsavir (2), the tromethamine salt of the phosphonooxymethyl prodrug of temsavir (1), encountered significant challenges at many points in the preclinical and clinical development program that, in many cases, stimulated the implementation of innovative solutions...

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Detalles Bibliográficos
Autores principales: Wang, Tao, Kadow, John F., Meanwell, Nicholas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476988/
https://www.ncbi.nlm.nih.gov/pubmed/34602806
http://dx.doi.org/10.1007/s00044-021-02787-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476988/
https://www.ncbi.nlm.nih.gov/pubmed/34602806
http://dx.doi.org/10.1007/s00044-021-02787-6

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