A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer

Scheduling anticancer drug administration over 24 h may critically impact treatment success in a patient-specific manner. Here, we address personalization of treatment timing using a novel mathematical model of irinotecan cellular pharmacokinetics and –dynamics linked to a representation of the core...

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Detalles Bibliográficos
Autores principales: Hesse, Janina, Martinelli, Julien, Aboumanify, Ouda, Ballesta, Annabelle, Relógio, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477139/
https://www.ncbi.nlm.nih.gov/pubmed/34630937
http://dx.doi.org/10.1016/j.csbj.2021.08.051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477139/
https://www.ncbi.nlm.nih.gov/pubmed/34630937
http://dx.doi.org/10.1016/j.csbj.2021.08.051

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