Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity

The normal androgen receptor (AR) cistrome and transcriptional program are fundamentally altered in prostate cancer (PCa). Here, we profile the chromatin landscape and AR-directed transcriptional program in normal prostate cells and show the impact of SPOP mutations, an early event in prostate tumor...

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Detalles Bibliográficos
Autores principales: Grbesa, Ivana, Augello, Michael A., Liu, Deli, McNally, Dylan R., Gaffney, Christopher D., Huang, Dennis, Lin, Kevin, Ivenitsky, Daria, Goueli, Ramy, Robinson, Brian D., Khani, Francesca, Deonarine, Lesa D., Blattner, Mirjam, Elemento, Olivier, Davicioni, Elai, Sboner, Andrea, Barbieri, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477443/
https://www.ncbi.nlm.nih.gov/pubmed/34496233
http://dx.doi.org/10.1016/j.celrep.2021.109625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477443/
https://www.ncbi.nlm.nih.gov/pubmed/34496233
http://dx.doi.org/10.1016/j.celrep.2021.109625

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