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Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity
The normal androgen receptor (AR) cistrome and transcriptional program are fundamentally altered in prostate cancer (PCa). Here, we profile the chromatin landscape and AR-directed transcriptional program in normal prostate cells and show the impact of SPOP mutations, an early event in prostate tumor...
Autores principales: | Grbesa, Ivana, Augello, Michael A., Liu, Deli, McNally, Dylan R., Gaffney, Christopher D., Huang, Dennis, Lin, Kevin, Ivenitsky, Daria, Goueli, Ramy, Robinson, Brian D., Khani, Francesca, Deonarine, Lesa D., Blattner, Mirjam, Elemento, Olivier, Davicioni, Elai, Sboner, Andrea, Barbieri, Christopher E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477443/ https://www.ncbi.nlm.nih.gov/pubmed/34496233 http://dx.doi.org/10.1016/j.celrep.2021.109625 |
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