The impact of anionic polymers on gene delivery: how composition and assembly help evading the toxicity-efficiency dilemma

Cationic polymers have been widely studied for non-viral gene delivery due to their ability to bind genetic material and to interact with cellular membranes. However, their charged nature carries the risk of increased cytotoxicity and interaction with serum proteins, limiting their potential in vivo...

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Detalles Bibliográficos
Autores principales: Richter, Friederike, Leer, Katharina, Martin, Liam, Mapfumo, Prosper, Solomun, Jana I., Kuchenbrod, Maren T., Hoeppener, Stephanie, Brendel, Johannes C., Traeger, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477462/
https://www.ncbi.nlm.nih.gov/pubmed/34579715
http://dx.doi.org/10.1186/s12951-021-00994-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477462/
https://www.ncbi.nlm.nih.gov/pubmed/34579715
http://dx.doi.org/10.1186/s12951-021-00994-2

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