Simultaneous Pharmacologic Inhibition of Yes‐Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic‐co‐Glycolic) Acid–Encapsulated Microparticles Improves Pulmonary Hypertension

BACKGROUND: Pulmonary hypertension (PH) is a deadly disease characterized by vascular stiffness and altered cellular metabolism. Current treatments focus on vasodilation and not other root causes of pathogenesis. Previously, it was demonstrated that glutamine metabolism, as catalyzed by GLS1 (glutam...

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Detalles Bibliográficos
Autores principales: Acharya, Abhinav P., Tang, Ying, Bertero, Thomas, Tai, Yi‐Yin, Harvey, Lloyd D., Woodcock, Chen‐Shan C., Sun, Wei, Pineda, Ricardo, Mitash, Nilay, Königshoff, Melanie, Little, Steven R., Chan, Stephen Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477870/
https://www.ncbi.nlm.nih.gov/pubmed/34056915
http://dx.doi.org/10.1161/JAHA.120.019091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477870/
https://www.ncbi.nlm.nih.gov/pubmed/34056915
http://dx.doi.org/10.1161/JAHA.120.019091

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