Antibody:CD47 ratio regulates macrophage phagocytosis through competitive receptor phosphorylation

Cancer immunotherapies often modulate macrophage effector function by introducing either targeting antibodies that activate Fcγ receptors (FcγRs) or blocking antibodies that disrupt inhibitory SIRPα-CD47 engagement. However, how these competing signals are integrated is poorly understood, raising qu...

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Detalles Bibliográficos
Autores principales: Suter, Emily C., Schmid, Eva M., Harris, Andrew R., Voets, Erik, Francica, Brian, Fletcher, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477956/
https://www.ncbi.nlm.nih.gov/pubmed/34433055
http://dx.doi.org/10.1016/j.celrep.2021.109587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477956/
https://www.ncbi.nlm.nih.gov/pubmed/34433055
http://dx.doi.org/10.1016/j.celrep.2021.109587

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