Cargando…

Antibody:CD47 ratio regulates macrophage phagocytosis through competitive receptor phosphorylation

Cancer immunotherapies often modulate macrophage effector function by introducing either targeting antibodies that activate Fcγ receptors (FcγRs) or blocking antibodies that disrupt inhibitory SIRPα-CD47 engagement. However, how these competing signals are integrated is poorly understood, raising qu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suter, Emily C., Schmid, Eva M., Harris, Andrew R., Voets, Erik, Francica, Brian, Fletcher, Daniel A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477956/ https://www.ncbi.nlm.nih.gov/pubmed/34433055 http://dx.doi.org/10.1016/j.celrep.2021.109587

Ejemplares similares

CD47 promotes ovarian cancer progression by inhibiting macrophage phagocytosis
por: Liu, Ran, et al.
Publicado: (2017)

Luteolin promotes macrophage-mediated phagocytosis by inhibiting CD47 pyroglutamation
por: Li, Zhiqiang, et al.
Publicado: (2021)

HIV-1 Vpu Promotes Phagocytosis of Infected CD4(+) T Cells by Macrophages through Downregulation of CD47
por: Cong, Lijun, et al.
Publicado: (2021)

CD47 blocking antibodies restore phagocytosis and prevent atherosclerosis
por: Kojima, Yoko, et al.
Publicado: (2016)

Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy
por: Zhu, Huaiyang, et al.
Publicado: (2017)

CD47 decline in pancreatic islet cells promotes macrophage-mediated phagocytosis in type I diabetes
por: Zhang, Jing, et al.
Publicado: (2020)

Dual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages
por: Zeller, Tobias, et al.
Publicado: (2022)

Targeting CD47 in Anaplastic Thyroid Carcinoma Enhances Tumor Phagocytosis by Macrophages and Is a Promising Therapeutic Strategy
por: Schürch, Christian M., et al.
Publicado: (2019)

CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE
por: Wang, Huan, et al.
Publicado: (2021)

CD47 blockade enhances phagocytosis of cardiac cell debris by neutrophils
por: Haj-Yehia, Elias, et al.
Publicado: (2023)

CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals
por: Li, Yang, et al.
Publicado: (2022)

MIR-708 promotes phagocytosis to eradicate T-ALL cells by targeting CD47
por: Huang, Wei, et al.
Publicado: (2018)

Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis
por: He, Yuan, et al.
Publicado: (2019)

Tristetraprolin regulates phagocytosis through interaction with CD47 in head and neck cancer
por: Lee, Won Hyeok, et al.
Publicado: (2022)

Attenuation of CD47-SIRPα Signal in Cholangiocarcinoma Potentiates Tumor-Associated Macrophage-Mediated Phagocytosis and Suppresses Intrahepatic Metastasis()()
por: Vaeteewoottacharn, Kulthida, et al.
Publicado: (2018)

Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo
por: Zhang, Michael, et al.
Publicado: (2016)

Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages
por: Gitik, Miri, et al.
Publicado: (2023)

Interleukin 4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation
por: Peña-Martínez, Pablo, et al.
Publicado: (2021)

CD47 Blockade Inhibits Tumor Progression through Promoting Phagocytosis of Tumor Cells by M2 Polarized Macrophages in Endometrial Cancer
por: Gu, Shenglan, et al.
Publicado: (2018)

Restoration of miR-340 controls pancreatic cancer cell CD47 expression to promote macrophage phagocytosis and enhance antitumor immunity
por: Xi, Qing, et al.
Publicado: (2020)

MicroRNA-200a Promotes Phagocytosis of Macrophages and Suppresses Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma by Targeting CD47
por: Zhao, Yunteng, et al.
Publicado: (2020)

TIGIT blockade repolarizes AML-associated TIGIT(+) M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis
por: Brauneck, Franziska, et al.
Publicado: (2022)

Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages
Publicado: (1993)

Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages via the Fc domain, resulting in cell death by phagoptosis
por: Métayer, Lucy E., et al.
Publicado: (2017)

TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets
por: Lin, Gloria H. Y., et al.
Publicado: (2017)

Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair
por: Zhang, Shuang, et al.
Publicado: (2017)

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes
por: Gitik, Miri, et al.
Publicado: (2011)

Elimination of Cancer Cells in Co-Culture: Role of Different Nanocarriers in Regulation of CD47 and Calreticulin-Induced Phagocytosis
por: Hassan, Eman M., et al.
Publicado: (2023)

Viral Inhibition of Bacterial Phagocytosis by Human Macrophages: Redundant Role of CD36
por: Cooper, Grace E., et al.
Publicado: (2016)

Prognostic Signature Development on the Basis of Macrophage Phagocytosis-Mediated Oxidative Phosphorylation in Bladder Cancer
por: Qu, Genyi, et al.
Publicado: (2022)

Macrophage deformability and phagocytosis
por: Mazur, MT, et al.
Publicado: (1977)

Cd47-Signal Regulatory Protein α (Sirpα) Regulates Fcγ and Complement Receptor–Mediated Phagocytosis
por: Oldenborg, Per-Arne, et al.
Publicado: (2001)

Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade
por: Anderson, Katie L., et al.
Publicado: (2020)

Neutrophil Functional Heterogeneity: Identification of Competitive Phagocytosis
por: Hellebrekers, Pien, et al.
Publicado: (2017)

CD47 expression and CD163(+) macrophages correlated with prognosis of pancreatic neuroendocrine tumor
por: Imam, Rami, et al.
Publicado: (2021)

Role of phagocytosis in the activation of macrophages
por: Schnyder, J, et al.
Publicado: (1978)

PEGylated and CD47-conjugated nanoellipsoidal artificial antigen-presenting cells minimize phagocytosis and augment anti-tumor T-cell responses
por: Song, Shilong, et al.
Publicado: (2019)

CD47 overexpression is associated with decreased neutrophil apoptosis/phagocytosis and poor prognosis in non-small-cell lung cancer patients
por: Barrera, Lourdes, et al.
Publicado: (2017)

Therapeutic Targeting of the Macrophage Immune Checkpoint CD47 in Myeloid Malignancies
por: Chao, Mark P., et al.
Publicado: (2020)

The application of HER2 and CD47 CAR-macrophage in ovarian cancer
por: Chen, Yizhao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ojvhg7d2uon0iin83nmr28se36