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Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo

During embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs). Although previous studies have shown that yolk-sac-derived erythromyeloid progenitors and HSCs emerge from distinct populations of...

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Detalles Bibliográficos
Autores principales: Dignum, Tessa, Varnum-Finney, Barbara, Srivatsan, Sanjay R., Dozono, Stacey, Waltner, Olivia, Heck, Adam M., Ishida, Takashi, Nourigat-McKay, Cynthia, Jackson, Dana L., Rafii, Shahin, Trapnell, Cole, Bernstein, Irwin D., Hadland, Brandon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478150/
https://www.ncbi.nlm.nih.gov/pubmed/34525376
http://dx.doi.org/10.1016/j.celrep.2021.109675