Modulation of heterologous protein secretion in the thermotolerant methylotrophic yeast Ogataea thermomethanolica TBRC 656 by CRISPR-Cas9 system

The thermotolerant methylotrophic yeast Ogataea thermomethanolica TBRC 656 is a potential host strain for industrial protein production. Heterologous proteins are often retained intracellularly in yeast resulting in endoplasmic reticulum (ER) stress and poor secretion, and despite efforts to enginee...

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Detalles Bibliográficos
Autores principales: Kruasuwan, Worarat, Puseenam, Aekkachai, Phithakrotchanakoon, Chitwadee, Tanapongpipat, Sutipa, Roongsawang, Niran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478189/
https://www.ncbi.nlm.nih.gov/pubmed/34582499
http://dx.doi.org/10.1371/journal.pone.0258005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478189/
https://www.ncbi.nlm.nih.gov/pubmed/34582499
http://dx.doi.org/10.1371/journal.pone.0258005

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