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Protein structural features predict responsiveness to pharmacological chaperone treatment for three lysosomal storage disorders
Three-dimensional structures of proteins can provide important clues into the efficacy of personalized treatment. We perform a structural analysis of variants within three inherited lysosomal storage disorders, comparing variants responsive to pharmacological chaperone treatment to those unresponsiv...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478239/ https://www.ncbi.nlm.nih.gov/pubmed/34529671 http://dx.doi.org/10.1371/journal.pcbi.1009370 |