A Method for Overcoming Plasma Protein Inhibition of Tyrosine Kinase Inhibitors

FMS-like tyrosine kinase 3 (FLT3) is the most frequently mutated gene in acute myeloid leukemia and a target for tyrosine kinase inhibitors (TKI). FLT3 TKIs have yielded limited improvements to clinical outcomes. One reason for this is TKI inhibition by endogenous factors. We characterized plasma pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Young, David J., Nguyen, Bao, Li, Li, Higashimoto, Tomoyasu, Levis, Mark J., Liu, Jun O., Small, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478262/
https://www.ncbi.nlm.nih.gov/pubmed/34589716
http://dx.doi.org/10.1158/2643-3230.BCD-20-0119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478262/
https://www.ncbi.nlm.nih.gov/pubmed/34589716
http://dx.doi.org/10.1158/2643-3230.BCD-20-0119

Ejemplares similares