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A Method for Overcoming Plasma Protein Inhibition of Tyrosine Kinase Inhibitors

FMS-like tyrosine kinase 3 (FLT3) is the most frequently mutated gene in acute myeloid leukemia and a target for tyrosine kinase inhibitors (TKI). FLT3 TKIs have yielded limited improvements to clinical outcomes. One reason for this is TKI inhibition by endogenous factors. We characterized plasma pr...

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Detalles Bibliográficos
Autores principales: Young, David J., Nguyen, Bao, Li, Li, Higashimoto, Tomoyasu, Levis, Mark J., Liu, Jun O., Small, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478262/
https://www.ncbi.nlm.nih.gov/pubmed/34589716
http://dx.doi.org/10.1158/2643-3230.BCD-20-0119