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A Method for Overcoming Plasma Protein Inhibition of Tyrosine Kinase Inhibitors
FMS-like tyrosine kinase 3 (FLT3) is the most frequently mutated gene in acute myeloid leukemia and a target for tyrosine kinase inhibitors (TKI). FLT3 TKIs have yielded limited improvements to clinical outcomes. One reason for this is TKI inhibition by endogenous factors. We characterized plasma pr...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478262/ https://www.ncbi.nlm.nih.gov/pubmed/34589716 http://dx.doi.org/10.1158/2643-3230.BCD-20-0119 |