A probabilistic framework for cellular lineage reconstruction using integrated single-cell 5-hydroxymethylcytosine and genomic DNA sequencing

Lineage reconstruction is central to understanding tissue development and maintenance. To overcome the limitations of current techniques that typically reconstruct clonal trees using genetically encoded reporters, we report scPECLR, a probabilistic algorithm to endogenously infer lineage trees at a...

Descripción completa

Detalles Bibliográficos
Autores principales: Wangsanuwat, Chatarin, Chialastri, Alex, Aldeguer, Javier F., Rivron, Nicolas C., Dey, Siddharth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478284/
https://www.ncbi.nlm.nih.gov/pubmed/34590075
http://dx.doi.org/10.1016/j.crmeth.2021.100060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478284/
https://www.ncbi.nlm.nih.gov/pubmed/34590075
http://dx.doi.org/10.1016/j.crmeth.2021.100060

Ejemplares similares