Signaling through TLR5 mitigates lethal radiation damage by neutrophil-dependent release of MMP-9

Acute radiation syndrome (ARS) is a major cause of lethality following radiation disasters. A TLR5 agonist, entolimod, is among the most powerful experimental radiation countermeasures and shows efficacy in rodents and non-human primates as a prophylactic (radioprotection) and treatment (radiomitiga...

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Detalles Bibliográficos
Autores principales: Brackett, Craig M., Greene, Kellee F., Aldrich, Alyssa R., Trageser, Nicholas H., Pal, Srabani, Molodtsov, Ivan, Kandar, Bojidar M., Burdelya, Lyudmila G., Abrams, Scott I., Gudkov, Andrei V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478872/
https://www.ncbi.nlm.nih.gov/pubmed/34584068
http://dx.doi.org/10.1038/s41420-021-00642-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478872/
https://www.ncbi.nlm.nih.gov/pubmed/34584068
http://dx.doi.org/10.1038/s41420-021-00642-6

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