Supercoiling and looping promote DNA base accessibility and coordination among distant sites

DNA in cells is supercoiled and constrained into loops and this supercoiling and looping influence every aspect of DNA activity. We show here that negative supercoiling transmits mechanical stress along the DNA backbone to disrupt base pairing at specific distant sites. Cooperativity among distant s...

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Detalles Bibliográficos
Autores principales: Fogg, Jonathan M., Judge, Allison K., Stricker, Erik, Chan, Hilda L., Zechiedrich, Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478907/
https://www.ncbi.nlm.nih.gov/pubmed/34584096
http://dx.doi.org/10.1038/s41467-021-25936-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478907/
https://www.ncbi.nlm.nih.gov/pubmed/34584096
http://dx.doi.org/10.1038/s41467-021-25936-2

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