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Natural selection at the RASGEF1C (GGC) repeat in human and divergent genotypes in late-onset neurocognitive disorder

Expression dysregulation of the neuron-specific gene, RASGEF1C (RasGEF Domain Family Member 1C), occurs in late-onset neurocognitive disorders (NCDs), such as Alzheimer’s disease. This gene contains a (GGC)13, spanning its core promoter and 5′ untranslated region (RASGEF1C-201 ENST00000361132.9). He...

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Detalles Bibliográficos
Autores principales: Jafarian, Z., Khamse, S., Afshar, H., Khorshid, H.R. Khorram, Delbari, A., Ohadi, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479062/
https://www.ncbi.nlm.nih.gov/pubmed/34584172
http://dx.doi.org/10.1038/s41598-021-98725-y