Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity

Idiosyncratic drug toxicity (IDT) associated with specific human leukocyte antigen (HLA) allotype is a rare and unpredictable life-threatening adverse drug reaction for which prospective mechanistic studies in humans are difficult. Here, we show the importance of immune tolerance for IDT onset and d...

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Detalles Bibliográficos
Autores principales: Susukida, Takeshi, Kuwahara, Saki, Song, Binbin, Kazaoka, Akira, Aoki, Shigeki, Ito, Kousei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479119/
https://www.ncbi.nlm.nih.gov/pubmed/34584206
http://dx.doi.org/10.1038/s42003-021-02657-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479119/
https://www.ncbi.nlm.nih.gov/pubmed/34584206
http://dx.doi.org/10.1038/s42003-021-02657-2

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