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Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity

Idiosyncratic drug toxicity (IDT) associated with specific human leukocyte antigen (HLA) allotype is a rare and unpredictable life-threatening adverse drug reaction for which prospective mechanistic studies in humans are difficult. Here, we show the importance of immune tolerance for IDT onset and d...

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Detalles Bibliográficos
Autores principales:	Susukida, Takeshi, Kuwahara, Saki, Song, Binbin, Kazaoka, Akira, Aoki, Shigeki, Ito, Kousei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479119/ https://www.ncbi.nlm.nih.gov/pubmed/34584206 http://dx.doi.org/10.1038/s42003-021-02657-2

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