The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops

Chromosomal rearrangements are a frequent cause of oncogene deregulation in human malignancies. Overexpression of EVI1 is found in a subgroup of acute myeloid leukemia (AML) with 3q26 chromosomal rearrangements, which is often therapy resistant. In AMLs harboring a t(3;8)(q26;q24), we observed the t...

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Detalles Bibliográficos
Autores principales: Ottema, Sophie, Mulet-Lazaro, Roger, Erpelinck-Verschueren, Claudia, van Herk, Stanley, Havermans, Marije, Arricibita Varea, Andrea, Vermeulen, Michael, Beverloo, H. Berna, Gröschel, Stefan, Haferlach, Torsten, Haferlach, Claudia, J. Wouters, Bas, Bindels, Eric, Smeenk, Leonie, Delwel, Ruud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479123/
https://www.ncbi.nlm.nih.gov/pubmed/34584081
http://dx.doi.org/10.1038/s41467-021-25862-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479123/
https://www.ncbi.nlm.nih.gov/pubmed/34584081
http://dx.doi.org/10.1038/s41467-021-25862-3

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