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A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease

Despite decades of use of low protein diets (LPD) in the management of chronic kidney disease (CKD), their mechanisms of action are unclear. A reduced production of uremic toxins could contribute to the benefits of LPDs. Aromatic amino-acids (AA) are precursors of major uremic toxins such as p-cresy...

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Autores principales: Barba, Christophe, Benoit, Bérengère, Bres, Emilie, Chanon, Stéphanie, Vieille-Marchiset, Aurélie, Pinteur, Claudie, Pesenti, Sandra, Glorieux, Griet, Picard, Cécile, Fouque, Denis, Soulage, Christophe O., Koppe, Laetitia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479128/
https://www.ncbi.nlm.nih.gov/pubmed/34584168
http://dx.doi.org/10.1038/s41598-021-98718-x
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author Barba, Christophe
Benoit, Bérengère
Bres, Emilie
Chanon, Stéphanie
Vieille-Marchiset, Aurélie
Pinteur, Claudie
Pesenti, Sandra
Glorieux, Griet
Picard, Cécile
Fouque, Denis
Soulage, Christophe O.
Koppe, Laetitia
author_facet Barba, Christophe
Benoit, Bérengère
Bres, Emilie
Chanon, Stéphanie
Vieille-Marchiset, Aurélie
Pinteur, Claudie
Pesenti, Sandra
Glorieux, Griet
Picard, Cécile
Fouque, Denis
Soulage, Christophe O.
Koppe, Laetitia
author_sort Barba, Christophe
collection PubMed
description Despite decades of use of low protein diets (LPD) in the management of chronic kidney disease (CKD), their mechanisms of action are unclear. A reduced production of uremic toxins could contribute to the benefits of LPDs. Aromatic amino-acids (AA) are precursors of major uremic toxins such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS). We hypothesize that a low aromatic amino acid diet (LA-AAD, namely a low intake of tyrosine, tryptophan and phenylalanine) while being normoproteic, could be as effective as a LPD, through the decreased production of uremic toxins. Kidney failure was chemically induced in mice with a diet containing 0.25% (w/w) of adenine. Mice received three different diets for six weeks: normoproteic diet (NPD: 14.7% proteins, aromatic AAs 0.019%), LPD (5% proteins, aromatic AAs 0.007%) and LA-AAD (14% proteins, aromatic AAs 0.007%). Both LPD and LA-AAD significantly reduced proteinuria, kidney fibrosis and inflammation. While LPD only slightly decreased plasma free PCS and free IS compared to NPD; free fractions of both compounds were significantly decreased by LA-AAD. These results suggest that a LA-AAD confers similar benefits of a LPD in delaying the progression of CKD through a reduction in some key uremic toxins production (such as PCS and IS), with a lower risk of malnutrition.
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spelling pubmed-84791282021-09-30 A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease Barba, Christophe Benoit, Bérengère Bres, Emilie Chanon, Stéphanie Vieille-Marchiset, Aurélie Pinteur, Claudie Pesenti, Sandra Glorieux, Griet Picard, Cécile Fouque, Denis Soulage, Christophe O. Koppe, Laetitia Sci Rep Article Despite decades of use of low protein diets (LPD) in the management of chronic kidney disease (CKD), their mechanisms of action are unclear. A reduced production of uremic toxins could contribute to the benefits of LPDs. Aromatic amino-acids (AA) are precursors of major uremic toxins such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS). We hypothesize that a low aromatic amino acid diet (LA-AAD, namely a low intake of tyrosine, tryptophan and phenylalanine) while being normoproteic, could be as effective as a LPD, through the decreased production of uremic toxins. Kidney failure was chemically induced in mice with a diet containing 0.25% (w/w) of adenine. Mice received three different diets for six weeks: normoproteic diet (NPD: 14.7% proteins, aromatic AAs 0.019%), LPD (5% proteins, aromatic AAs 0.007%) and LA-AAD (14% proteins, aromatic AAs 0.007%). Both LPD and LA-AAD significantly reduced proteinuria, kidney fibrosis and inflammation. While LPD only slightly decreased plasma free PCS and free IS compared to NPD; free fractions of both compounds were significantly decreased by LA-AAD. These results suggest that a LA-AAD confers similar benefits of a LPD in delaying the progression of CKD through a reduction in some key uremic toxins production (such as PCS and IS), with a lower risk of malnutrition. Nature Publishing Group UK 2021-09-28 /pmc/articles/PMC8479128/ /pubmed/34584168 http://dx.doi.org/10.1038/s41598-021-98718-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Barba, Christophe
Benoit, Bérengère
Bres, Emilie
Chanon, Stéphanie
Vieille-Marchiset, Aurélie
Pinteur, Claudie
Pesenti, Sandra
Glorieux, Griet
Picard, Cécile
Fouque, Denis
Soulage, Christophe O.
Koppe, Laetitia
A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
title A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
title_full A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
title_fullStr A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
title_full_unstemmed A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
title_short A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
title_sort low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479128/
https://www.ncbi.nlm.nih.gov/pubmed/34584168
http://dx.doi.org/10.1038/s41598-021-98718-x
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