Cargando…
A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
Despite decades of use of low protein diets (LPD) in the management of chronic kidney disease (CKD), their mechanisms of action are unclear. A reduced production of uremic toxins could contribute to the benefits of LPDs. Aromatic amino-acids (AA) are precursors of major uremic toxins such as p-cresy...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479128/ https://www.ncbi.nlm.nih.gov/pubmed/34584168 http://dx.doi.org/10.1038/s41598-021-98718-x |
_version_ | 1784576182583296000 |
---|---|
author | Barba, Christophe Benoit, Bérengère Bres, Emilie Chanon, Stéphanie Vieille-Marchiset, Aurélie Pinteur, Claudie Pesenti, Sandra Glorieux, Griet Picard, Cécile Fouque, Denis Soulage, Christophe O. Koppe, Laetitia |
author_facet | Barba, Christophe Benoit, Bérengère Bres, Emilie Chanon, Stéphanie Vieille-Marchiset, Aurélie Pinteur, Claudie Pesenti, Sandra Glorieux, Griet Picard, Cécile Fouque, Denis Soulage, Christophe O. Koppe, Laetitia |
author_sort | Barba, Christophe |
collection | PubMed |
description | Despite decades of use of low protein diets (LPD) in the management of chronic kidney disease (CKD), their mechanisms of action are unclear. A reduced production of uremic toxins could contribute to the benefits of LPDs. Aromatic amino-acids (AA) are precursors of major uremic toxins such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS). We hypothesize that a low aromatic amino acid diet (LA-AAD, namely a low intake of tyrosine, tryptophan and phenylalanine) while being normoproteic, could be as effective as a LPD, through the decreased production of uremic toxins. Kidney failure was chemically induced in mice with a diet containing 0.25% (w/w) of adenine. Mice received three different diets for six weeks: normoproteic diet (NPD: 14.7% proteins, aromatic AAs 0.019%), LPD (5% proteins, aromatic AAs 0.007%) and LA-AAD (14% proteins, aromatic AAs 0.007%). Both LPD and LA-AAD significantly reduced proteinuria, kidney fibrosis and inflammation. While LPD only slightly decreased plasma free PCS and free IS compared to NPD; free fractions of both compounds were significantly decreased by LA-AAD. These results suggest that a LA-AAD confers similar benefits of a LPD in delaying the progression of CKD through a reduction in some key uremic toxins production (such as PCS and IS), with a lower risk of malnutrition. |
format | Online Article Text |
id | pubmed-8479128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84791282021-09-30 A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease Barba, Christophe Benoit, Bérengère Bres, Emilie Chanon, Stéphanie Vieille-Marchiset, Aurélie Pinteur, Claudie Pesenti, Sandra Glorieux, Griet Picard, Cécile Fouque, Denis Soulage, Christophe O. Koppe, Laetitia Sci Rep Article Despite decades of use of low protein diets (LPD) in the management of chronic kidney disease (CKD), their mechanisms of action are unclear. A reduced production of uremic toxins could contribute to the benefits of LPDs. Aromatic amino-acids (AA) are precursors of major uremic toxins such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS). We hypothesize that a low aromatic amino acid diet (LA-AAD, namely a low intake of tyrosine, tryptophan and phenylalanine) while being normoproteic, could be as effective as a LPD, through the decreased production of uremic toxins. Kidney failure was chemically induced in mice with a diet containing 0.25% (w/w) of adenine. Mice received three different diets for six weeks: normoproteic diet (NPD: 14.7% proteins, aromatic AAs 0.019%), LPD (5% proteins, aromatic AAs 0.007%) and LA-AAD (14% proteins, aromatic AAs 0.007%). Both LPD and LA-AAD significantly reduced proteinuria, kidney fibrosis and inflammation. While LPD only slightly decreased plasma free PCS and free IS compared to NPD; free fractions of both compounds were significantly decreased by LA-AAD. These results suggest that a LA-AAD confers similar benefits of a LPD in delaying the progression of CKD through a reduction in some key uremic toxins production (such as PCS and IS), with a lower risk of malnutrition. Nature Publishing Group UK 2021-09-28 /pmc/articles/PMC8479128/ /pubmed/34584168 http://dx.doi.org/10.1038/s41598-021-98718-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Barba, Christophe Benoit, Bérengère Bres, Emilie Chanon, Stéphanie Vieille-Marchiset, Aurélie Pinteur, Claudie Pesenti, Sandra Glorieux, Griet Picard, Cécile Fouque, Denis Soulage, Christophe O. Koppe, Laetitia A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease |
title | A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease |
title_full | A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease |
title_fullStr | A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease |
title_full_unstemmed | A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease |
title_short | A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease |
title_sort | low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479128/ https://www.ncbi.nlm.nih.gov/pubmed/34584168 http://dx.doi.org/10.1038/s41598-021-98718-x |
work_keys_str_mv | AT barbachristophe alowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT benoitberengere alowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT bresemilie alowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT chanonstephanie alowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT vieillemarchisetaurelie alowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT pinteurclaudie alowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT pesentisandra alowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT glorieuxgriet alowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT picardcecile alowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT fouquedenis alowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT soulagechristopheo alowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT koppelaetitia alowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT barbachristophe lowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT benoitberengere lowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT bresemilie lowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT chanonstephanie lowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT vieillemarchisetaurelie lowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT pinteurclaudie lowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT pesentisandra lowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT glorieuxgriet lowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT picardcecile lowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT fouquedenis lowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT soulagechristopheo lowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease AT koppelaetitia lowaromaticaminoaciddietimprovesrenalfunctionandpreventkidneyfibrosisinmicewithchronickidneydisease |