DNA Damage Response and Repair Gene Alterations Increase Tumor Mutational Burden and Promote Poor Prognosis of Advanced Lung Cancer

DNA damage response and repair (DDR) gene alterations increase tumor-infiltrating lymphocytes, genomic instability, and tumor mutational burden (TMB). Whether DDR-related alterations relate to therapeutic response and prognosis in lung cancer lacking oncogenic drivers remains unknown. Pretherapeutic...

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Detalles Bibliográficos
Autores principales: Dai, Jiawei, Jiang, Minlin, He, Kan, Wang, Hao, Chen, Peixin, Guo, Haoyue, Zhao, Wencheng, Lu, Hui, He, Yayi, Zhou, Caicun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479169/
https://www.ncbi.nlm.nih.gov/pubmed/34604048
http://dx.doi.org/10.3389/fonc.2021.708294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479169/
https://www.ncbi.nlm.nih.gov/pubmed/34604048
http://dx.doi.org/10.3389/fonc.2021.708294

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