STAT3-Specific Single Domain Nanobody Inhibits Expansion of Pathogenic Th17 Responses and Suppresses Uveitis in Mice

STAT3 activates transcription of genes that regulate cell growth, differentiation, and survival of mammalian cells. Genetic deletion of Stat3 in T cells has been shown to abrogate Th17 differentiation, suggesting that STAT3 is a potential therapeutic target for Th17-mediated diseases. However, a maj...

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Detalles Bibliográficos
Autores principales: Mbanefo, Evaristus C., Yan, Ming, Kang, Minkyung, Alhakeem, Sahar A., Jittayasothorn, Yingyos, Yu, Cheng-Rong, Parihar, Ashutosh, Singh, Sunanda, Egwuagu, Charles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479182/
https://www.ncbi.nlm.nih.gov/pubmed/34603297
http://dx.doi.org/10.3389/fimmu.2021.724609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479182/
https://www.ncbi.nlm.nih.gov/pubmed/34603297
http://dx.doi.org/10.3389/fimmu.2021.724609

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