Inhibition of IP3R/Ca2+ Dysregulation Protects Mice From Ventilator-Induced Lung Injury via Endoplasmic Reticulum and Mitochondrial Pathways

RATIONALE: Disruption of intracellular calcium (Ca2+) homeostasis is implicated in inflammatory responses. Here we investigated endoplasmic reticulum (ER) Ca2+ efflux through the Inositol 1,4,5-trisphosphate receptor (IP3R) as a potential mechanism of inflammatory pathophysiology in a ventilator-ind...

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Detalles Bibliográficos
Autores principales: Ye, Liu, Zeng, Qi, Ling, Maoyao, Ma, Riliang, Chen, Haishao, Lin, Fei, Li, Zhao, Pan, Linghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479188/
https://www.ncbi.nlm.nih.gov/pubmed/34603302
http://dx.doi.org/10.3389/fimmu.2021.729094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479188/
https://www.ncbi.nlm.nih.gov/pubmed/34603302
http://dx.doi.org/10.3389/fimmu.2021.729094

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