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Low folate induces abnormal neuronal maturation and DNA hypomethylation of neuronal differentiation-related genes in cultured mouse neural stem and progenitor cells
Folate deficiency in a fetus is well known to cause neurodevelopment defects and development disorders. A low level of folate is also thought to be a risk for depression in adults. We have previously shown that post-weaning low folate induces neuronal immaturity in the dentate gyrus in mice, which s...
Autores principales: | Araki, Ryota, Nishida, Shoji, Nakajima, Yuki, Iwakumo, Arimi, Tachioka, Hayato, Kita, Ayami, Yabe, Takeshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479244/ https://www.ncbi.nlm.nih.gov/pubmed/34622073 http://dx.doi.org/10.1016/j.heliyon.2021.e08071 |
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