Essential role of ALKBH5-mediated RNA demethylation modification in bile acid-induced gastric intestinal metaplasia

Bile acid reflux and subsequent caudal-related homeobox 2 (CDX2) activation contribute to gastric intestinal metaplasia (IM), a precursor of gastric cancer; however, the mechanism underlying this phenomenon is unclear. Here, we demonstrate that alkylation repair homolog protein 5 (ALKBH5), a major R...

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Detalles Bibliográficos
Autores principales: Yue, Ben, Cui, Ran, Zheng, Ruizhe, Jin, Weilin, Song, Chenlong, Bao, Tianshang, Wang, Ming, Yu, Fengrong, Zhao, Enhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479281/
https://www.ncbi.nlm.nih.gov/pubmed/34631277
http://dx.doi.org/10.1016/j.omtn.2021.08.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479281/
https://www.ncbi.nlm.nih.gov/pubmed/34631277
http://dx.doi.org/10.1016/j.omtn.2021.08.019

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