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Essential role of ALKBH5-mediated RNA demethylation modification in bile acid-induced gastric intestinal metaplasia
Bile acid reflux and subsequent caudal-related homeobox 2 (CDX2) activation contribute to gastric intestinal metaplasia (IM), a precursor of gastric cancer; however, the mechanism underlying this phenomenon is unclear. Here, we demonstrate that alkylation repair homolog protein 5 (ALKBH5), a major R...
Autores principales: | Yue, Ben, Cui, Ran, Zheng, Ruizhe, Jin, Weilin, Song, Chenlong, Bao, Tianshang, Wang, Ming, Yu, Fengrong, Zhao, Enhao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479281/ https://www.ncbi.nlm.nih.gov/pubmed/34631277 http://dx.doi.org/10.1016/j.omtn.2021.08.019 |
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