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Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope
Base editors are RNA-guided deaminases that enable site-specific nucleotide transitions. The targeting scope of these Cas-deaminase fusion proteins critically depends on the availability of a protospacer adjacent motif (PAM) at the target locus and is limited to a window within the CRISPR-Cas R-loop...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479293/ https://www.ncbi.nlm.nih.gov/pubmed/34631280 http://dx.doi.org/10.1016/j.omtn.2021.08.025 |