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Modified reference based imputation and tipping point analysis in the presence of missing data due to COVID-19
In longitudinal clinical trials, missing data are inevitable due to intercurrent events (ICEs) such as treatment interruption or premature discontinuation for different reasons. The COVID-19 pandemic has had substantial impact on clinical trials since early 2020 as it may result in missing data due...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479366/ https://www.ncbi.nlm.nih.gov/pubmed/34597836 http://dx.doi.org/10.1016/j.cct.2021.106575 |