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Direct detection of the myosin super-relaxed state and interacting-heads motif in solution

The interacting-heads motif (IHM) is a structure of myosin that has been proposed to modulate cardiac output by occluding myosin molecules from undergoing the force-generating cycle. It is hypothesized to be the structural basis for the super-relaxed state (SRX), a low-ATPase kinetic state thought t...

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Detalles Bibliográficos
Autores principales: Chu, Sami, Muretta, Joseph M., Thomas, David D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479475/
https://www.ncbi.nlm.nih.gov/pubmed/34481842
http://dx.doi.org/10.1016/j.jbc.2021.101157