Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin

The hepatic carbohydrate-recognizing asialoglycoprotein receptor (ASGR1) mediates the endocytosis/lysosomal degradation of desialylated glycoproteins following binding to terminal galactose/N-acetylgalactosamine. Human heterozygote carriers of ASGR1 deletions exhibit ∼34% lower risk of coronary arte...

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Detalles Bibliográficos
Autores principales: Susan-Resiga, Delia, Girard, Emmanuelle, Essalmani, Rachid, Roubtsova, Anna, Marcinkiewicz, Jadwiga, Derbali, Rabeb M., Evagelidis, Alexandra, Byun, Jae H., Lebeau, Paul F., Austin, Richard C., Seidah, Nabil G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479480/
https://www.ncbi.nlm.nih.gov/pubmed/34508778
http://dx.doi.org/10.1016/j.jbc.2021.101177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479480/
https://www.ncbi.nlm.nih.gov/pubmed/34508778
http://dx.doi.org/10.1016/j.jbc.2021.101177

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