R-2HG downregulates ERα to inhibit cholangiocarcinoma via the FTO/m6A-methylated ERα/miR16-5p/YAP1 signal pathway

Isocitrate dehydrogenase (IDH) mutations increase (R)-2-hydroxyglutarate (R-2HG) production; however, functional mechanisms of R-2HG in regulating cholangiocarcinoma (CCA) development remain to be further investigated. We first applied the CRISPR-Cas9 gene-editing system to create IDH1R132H-mutated...

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Detalles Bibliográficos
Autores principales: Gao, Yuan, Ouyang, Xiwu, Zuo, Li, Xiao, Yao, Sun, Yin, Chang, Chawnshang, Qin, Xihu, Yeh, Shuyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479483/
https://www.ncbi.nlm.nih.gov/pubmed/34632051
http://dx.doi.org/10.1016/j.omto.2021.06.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479483/
https://www.ncbi.nlm.nih.gov/pubmed/34632051
http://dx.doi.org/10.1016/j.omto.2021.06.017

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