Cargando…
R-2HG downregulates ERα to inhibit cholangiocarcinoma via the FTO/m6A-methylated ERα/miR16-5p/YAP1 signal pathway
Isocitrate dehydrogenase (IDH) mutations increase (R)-2-hydroxyglutarate (R-2HG) production; however, functional mechanisms of R-2HG in regulating cholangiocarcinoma (CCA) development remain to be further investigated. We first applied the CRISPR-Cas9 gene-editing system to create IDH1R132H-mutated...
Autores principales: | Gao, Yuan, Ouyang, Xiwu, Zuo, Li, Xiao, Yao, Sun, Yin, Chang, Chawnshang, Qin, Xihu, Yeh, Shuyuan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479483/ https://www.ncbi.nlm.nih.gov/pubmed/34632051 http://dx.doi.org/10.1016/j.omto.2021.06.017 |
Ejemplares similares
-
YAP inhibits ERα and ER(+) breast cancer growth by disrupting a TEAD-ERα signaling axis
por: Li, Xu, et al.
Publicado: (2022) -
Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERα
por: Ge, Luna, et al.
Publicado: (2018) -
miR-221/222 sponge abrogates tamoxifen resistance in ER-positive breast cancer cells through restoring the expression of ERα
por: Ouyang, Yan Xiu, et al.
Publicado: (2021) -
Apigenin Inhibits the Histamine-Induced Proliferation of Ovarian Cancer Cells by Downregulating ERα/ERβ Expression
por: Liu, Manman, et al.
Publicado: (2021) -
Deciphering of a Putative GPER Recognition Domain in ERα and ERα36
por: Acramel, Alexandre, et al.
Publicado: (2022)