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Conformational landscape of multidomain SMAD proteins

SMAD transcription factors, the main effectors of the TGFβ (transforming growth factor β) network, have a mixed architecture of globular domains and flexible linkers. Such a complicated architecture precluded the description of their full-length (FL) structure for many years. In this study, we unrav...

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Detalles Bibliográficos
Autores principales: Gomes, Tiago, Martin-Malpartida, Pau, Ruiz, Lidia, Aragón, Eric, Cordeiro, Tiago N., Macias, Maria J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479633/
https://www.ncbi.nlm.nih.gov/pubmed/34630939
http://dx.doi.org/10.1016/j.csbj.2021.09.009