Biosynthetic Crossover of 5-Lipoxygenase and Cyclooxygenase-2 Yields 5-Hydroxy-PGE(2) and 5-Hydroxy-PGD(2)

[Image: see text] The biosynthetic crossover of 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) enzymatic activities is a productive pathway to convert arachidonic acid into unique eicosanoids. Here, we show that COX-2 catalysis with 5-LOX derived 5-hydroxy-eicosatetraenoic acid yields the endop...

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Detalles Bibliográficos
Autores principales: Nakashima, Fumie, Suzuki, Takashi, Gordon, Odaine N., Golding, Dominic, Okuno, Toshiaki, Giménez-Bastida, Juan A., Yokomizo, Takehiko, Schneider, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479768/
https://www.ncbi.nlm.nih.gov/pubmed/34604848
http://dx.doi.org/10.1021/jacsau.1c00177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479768/
https://www.ncbi.nlm.nih.gov/pubmed/34604848
http://dx.doi.org/10.1021/jacsau.1c00177

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