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Intercalation Ability of Novel Monofunctional Platinum Anticancer Drugs: A Key Step in Their Biological Action

[Image: see text] Phenanthriplatin (PtPPH) is a monovalent platinum(II)-based complex with a large cytotoxicity against cancer cells. Although the aqua-activated drug has been assumed to be the precursor for DNA damage, it is still under debate whether the way in which that metallodrug attacks to DN...

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Detalles Bibliográficos
Autores principales: Veclani, Daniele, Tolazzi, Marilena, Cerón-Carrasco, José P., Melchior, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479807/
https://www.ncbi.nlm.nih.gov/pubmed/34156233
http://dx.doi.org/10.1021/acs.jcim.1c00430