The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

R-loops are a major source of genome instability associated with transcription-induced replication stress. However, how R-loops inherently impact replication fork progression is not understood. Here, we characterize R-loop-replisome collisions using a fully reconstituted eukaryotic DNA replication s...

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Detalles Bibliográficos
Autores principales: Kumar, Charanya, Batra, Sahil, Griffith, Jack D, Remus, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479836/
https://www.ncbi.nlm.nih.gov/pubmed/34494544
http://dx.doi.org/10.7554/eLife.72286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479836/
https://www.ncbi.nlm.nih.gov/pubmed/34494544
http://dx.doi.org/10.7554/eLife.72286

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