Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-κB signaling pathway and Nrf2/HO-1 axis

BACKGROUND: Exosomes are considered a substitute for stem cell-based therapy for myocardial infarction (MI). FNDC5, a transmembrane protein located in the cytoplasm, plays a crucial role in inflammation diseases and MI repair. Furthermore, our previous study found that FNDC5 pre-conditioning bone ma...

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Detalles Bibliográficos
Autores principales: Ning, Hongjuan, Chen, Haixu, Deng, Jingyu, Xiao, Chun, Xu, Moyan, Shan, Lina, Yang, Chao, Zhang, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480009/
https://www.ncbi.nlm.nih.gov/pubmed/34583757
http://dx.doi.org/10.1186/s13287-021-02591-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480009/
https://www.ncbi.nlm.nih.gov/pubmed/34583757
http://dx.doi.org/10.1186/s13287-021-02591-4

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