Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

Despite absent expression in normal hematopoiesis, the Forkhead factor FOXC1, a critical mesenchymal differentiation regulator, is highly expressed in ∼30% of HOXA(high) acute myeloid leukemia (AML) cases to confer blocked monocyte/macrophage differentiation. Through integrated proteomics and bioinf...

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Detalles Bibliográficos
Autores principales: Simeoni, Fabrizio, Romero-Camarero, Isabel, Camera, Francesco, Amaral, Fabio M.R., Sinclair, Oliver J., Papachristou, Evangelia K., Spencer, Gary J., Lie-A-Ling, Michael, Lacaud, Georges, Wiseman, Daniel H., Carroll, Jason S., Somervaille, Tim C.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480281/
https://www.ncbi.nlm.nih.gov/pubmed/34551306
http://dx.doi.org/10.1016/j.celrep.2021.109725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480281/
https://www.ncbi.nlm.nih.gov/pubmed/34551306
http://dx.doi.org/10.1016/j.celrep.2021.109725

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